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Médecine, Sciences et technologies
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Hard-to-find insights from industry professionals on success strategies for developing the next generation of antiviral blockbuster drugs Presented by industry…
professionals with a track record of discovering new drugs and treatments, Trends in Antiviral Drug Development describes successful development efforts for antiviral compounds and therapies that have entered the market or are currently in clinical trials. Viruses are ordered by their target tissue, in line with contemporary drug development that focuses on tissue-targeted therapeutics. Other key trends in antiviral therapy, such as the effort to develop long-acting drugs, are described for each virus type, enabling readers to follow the current and future state in this core area of contemporary drug development. Trends in Antiviral Drug Development includes discussion on: Novel drugs against herpes viruses as well as the breakthrough drugs that cured HCVsiRNA therapeutics, a new antiviral modality, and the drug candidates that are progressing toward achieving an HBV cureDrugs targeting viral entry, such as in HIV entry through attachment, co-receptor binding, and fusionNovel therapeutics against tropical diseases such as dengue fever and monkey pox Trends in Antiviral Drug Development is an essential read for medicinal chemists, pharmaceutical chemists, virologists, and all professionals seeking to understand new ideas and approaches to combat the ever-expanding universe of viral infections.
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Ouvrages documentaires canadiens, Drame
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On a publicity tour in Japan, Carl, a Canadian author, finds himself falling in love amidst the sacred stages of…
Noh theatre and the seedy dance clubs in Tokyo, wired on cocaine and sake. His object of affection is the young, seductive actor, Yori, but the affair becomes complicated when Carl’s translator and Yori’s sister, Nushi, becomes entranced with him. As his tour continues, he straddles the fragmentary place between two cultures—one of individuality and directness, the other of tradition and formality—and uncovers the dualities that exist in life and love. Based on The Tale of Genji, one of the world’s oldest pieces of literature, MacIvor’s script takes us into the centre of a clandestine Japan as experienced by the visiting outsider.
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Science-fiction, Fantastique (récits), Fantômes et horreur (récits)
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The #1 New York Times bestselling author of Year One and Of Blood and Bone concludes her stunning new trilogy…
praised as “A match for end-of-the-world classics like Stephen King’s The Stand.” After the sickness known as the Doom destroyed civilization, magick has become commonplace, and Fallon Swift has spent her young years learning its ways. Fallon cannot live in peace until she frees those who have been preyed upon by the government or the fanatical Purity Warriors, endlessly hunted or locked up in laboratories, brutalized for years on end. She is determined to save even those who have been complicit with this evil out of fear or weakness—if, indeed, they can be saved.Strengthened by the bond she shares with her fellow warrior, Duncan, Fallon has already succeeded in rescuing countless shifters and elves and ordinary humans. Now she must help them heal—and rediscover the light and faith within themselves. For although from the time of her birth, she has been The One, she is still only one. And as she faces down an old nemesis, sets her sights on the enemy’s stronghold, and pursues her destiny—to finally restore the mystical shield that once protected them all—she will need an army behind her…
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Littérature générale (romans)Etats-Unis (histoire)
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WINNER, IPPY BOOK AWARDS, LGBTQ+ FICTIONWINNER, 2023 BEST INDIE BOOK AWARD, LGBTQ2 FICTIONSHORT LIST, VCU CABELL FIRST NOVELIST AWARDON LAMBDA…
LITERARY REVIEW'S SEPTEMBER MOST ANTICIPATED LISTONE OF QUEER FORTY'S BEST PRIDE READS FOR SUMMER 2023!Three gay men in pre-Stonewall New York City find their fates thrown together in the police raid of a Village bar.Roger Moorhouse is a Wall Street banker and Westchester family man with a preciously guarded secret. As the shouting begins and flashlights blaze in his face, the life he’s carefully curated over the years—a fancy new office overlooking lower Broadway, a house in Beechmont Woods, his wife and children—is about to come crashing down around him.Columbia literature professor Julian Prince lives a comparatively uncloseted life when he finds his first committed relationship tested to its limits. How could he explain to Gus, a fearless young artist, that he couldn’t stay with him that weekend because the woman who was still technically Julian’s fiancée would be visiting? But when Gus is struck unconscious by a police baton, Julian comes out of hiding to protect him, even if exposure means losing everything.For Danny Duffy, an Irish kid from the Bronx with a sassy mouth and a diverse group of friends, the raid is a galvanizing, Spartacus moment. Danny doesn’t have too much left to lose; his family has just disowned him. But once his name appears in the newspaper, he’ll be fired from his job at Sloan’s Supermarket, where he’s risen to assistant manager of produce, and begin a journey that veers between political enlightenment and violent revenge.The three men find themselves in a police wagon together, their hidden lives threatened to be revealed to the world. Blackmail, a private investigator, Gus’s disappearance, and Danny’s quest for retribution propel Disorderly Men to its piercing conclusion, as each man meets the boundaries of his own fear, love, and shame. The stakes for each are different, but all of them confront a fundamental question: How much happiness is he allowed to have . . . and what share of it will he lay claim to?
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Littérature générale (romans)Etats-Unis (histoire), Essais et documents généraux
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Set in a rapidly gentrifying New York City determined to move beyond the decimation of a generation a decade earlier,…
What I Did Wrong is a day in the life of Tom, a forty-two-year-old English professor, haunted by the death of his best friend, Zack, who died theatrically and calamitously of AIDS. Tom himself slouches gingerly and precariously into middle age questioning every certainty he had about himself as a gay man while negotiating the field of his college classes, populated as they are with guys whose cocky bravado can’t quite compensate for their own confused masculinity. Tom tries to balance his awkwardly developing friendships with them. In the process, he begins to find common ground with these proud young men and, surprisingly, a way to claim his own place in the world, and in history.A powerfully moving—and often disarmingly funny—book about loss, character, and sexuality in the wake of AIDS, What I Did Wrong is a survivor’s tale in an age when all certainties have lost their logic and focus. It is a romance that embraces its objects from the traumas of toxic masculinity to the aftermath of catastrophic loss amidst the enduring allure of New York City in all its manic and heartbreaking grandeur.
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Littérature générale (romans)Etats-Unis (histoire), Essais et documents généraux
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Following the discovery of an anonymous libretto, Abner Blossom comes out of retirement to write an opera based on the…
life of infamous novelist-turned-photographer Cyril Vane. But those who knew Vane and his Russian-born wife, the silent-screen star Madame Olga Petrovna, are prepared to go to any length to suppress the truth about them. Vane’s dark secret follows him to the grave. But his jealous and vengeful widow and her faded cronies employ all the means at their disposal to prevent the opening of Blossom’s opera. Out with the Stars is peopled by the Gothic characters readers of James Purdy have come to anticipate and relish, from Val Sturgis, Kentucky boy made good and now Blossom’s protégé to Francis X. Beauregard, aging star of the silver screen now living surrounded by streetwise hustlers in his Brooklyn mansion.Back in print for the first time since 1993, Purdy’s flamboyant tale of New York City’s pre-Stonewall bohemia includes an incisive Foreword by Robert J. Corber, placing the work within its rich social and cultural context.
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Asie (histoire), Politique et gouvernement, Essais et documents généraux
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This volume studies the concept and relevance of HISTEM (History of Science, Technology, Environment, and Medicine) in shaping the histories…
of colonial and postcolonial South Asia. Tracing its evolution from the establishment of the East India Company through to the early decades after the Independence of India, it highlights the ways in which the discipline has changed over the years and examines the various influences that have shaped it. Drawing on extensive case studies, the book offers valuable insights into diverse themes such as the East-West encounter, appropriation of new knowledge, science in translation and communication, electricity and urbanization, the colonial context of engineering education, science of hydrology, oil and imperialism, epidemic and empire, vernacular medicine, gender and medicine, as well as environment and sustainable development in the colonial and post-colonial milieu. An indispensable text on South Asia’s experience of modernity in the nineteenth and twentieth centuries, this book will be of interest to scholars and researchers of modern South Asian studies, modern Indian history, sociology, history of science, cultural studies, colonialism, as well as studies on Science, Technology and Society (STS).
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Sciences et technologies
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Increased agricultural productivity is a major stepping stone on the path out of poverty in sub-Saharan Africa and South Asia,…
but farmers there face tremendous challenges improving production. Poor soil, inefficient water use, and a lack of access to plant breeding resources, nutritious animal feed, high quality seed, and fuel and electricity-combined with some of the most extreme environmental conditions on Earth-have made yields in crop and animal production far lower in these regions than world averages. Emerging Technologies to Benefit Farmers in Sub-Saharan Africa and South Asia identifies sixty emerging technologies with the potential to significantly improve agricultural productivity in sub-Saharan Africa and South Asia. Eighteen technologies are recommended for immediate development or further exploration. Scientists from all backgrounds have an opportunity to become involved in bringing these and other technologies to fruition. The opportunities suggested in this book offer new approaches that can synergize with each other and with many other activities to transform agriculture in sub-Saharan Africa and South Asia.
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Esta segunda edición de Los señores del narco, revisada y actualizada, incluye la entrevista inédita del Chapo con la DEA.Anabel…
Hernández tuvo acceso no sólo a una vasta documentación, inédita hasta hoy, sino a testimonios directos de autoridades y expertos en el tema, así como de personas involucradas con los principales cárteles mexicanos de la droga. Esto le ha permitido examinar rigurosamente el origen de la sangrienta lucha por el poder entre los grupos criminales, y cuestionar la "guerra" del gobierno federal contra la delincuencia organizada.Al investigar las intrincadas redes de contubernios, la autora tuvo que remontarse a la década de 1970, cuando se controlaba el tráfico de enervantes haciendo que los narcos prácticamente pagaran impuestos al gobierno. En su inquietante recorrido avanza hacia los años ochenta, cuando los jefes de la organización criminal del Pacífico, auspiciados por la CIA, incursionaron en el jugoso negocio de la cocaína,y nos conduce hasta el surgimiento de poderosos capos como los hermanos Beltrán Leyva, Ismael El Mayo Zambada o Joaquín Guzmán Loera, quienes lograron penetrar las estructuras del Estado y ponerlas a su servicio. Tras echar abajo el mito de la fuga de El Chapo de la prisión de Puente Grande en un carrito de lavandería, este libro narra su ascenso en la jerarquía del crimen y cómo ha llevado hasta sus últimas y terribles consecuencias un "pacto de impunidad" con numerosos funcionarios públicos y hombres de negocios.Este libro, en suma, se presenta como un impactante viaje al interior del mundo del narcotráfico para buscar los poderosos resortes que lo mueven, y los ha descubierto con nombre y apellido.
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Crime véritable
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El traidor es uno de los trabajos periodísticos más ambiciosos en la trayectoria de Anabel Hernández. El traidor es uno…
de los trabajos periodísticos más ambiciosos en la trayectoria de Anabel Hernández. Su historia se remonta a enero de 2011, cuando la contactó uno de los abogados de Vicente Zambada Niebla, mejor conocido como Vicentillo, quien enfrentaba un juicio en una corte de Chicago. La intención era compartir con la periodista documentos y hechos que ampliaban y esclarecían varios de los episodios que acababa de dar a conocer en Los señores del narco. Entre los documentos a los que tuvo acceso se encuentran el inquietante autorretrato como payaso que aparece en la portada y los diarios realizados por Vicentillo durante las negociaciones para colaborar con el gobierno norteamericano, los cuales hasta ahora eran secretos. En ellos el capo reconstruyó su historia y la historia de una de las organizaciones de tráfico de estupefacientes más grandes del planeta. A lo largo de estas páginas, la autora se adentra en el Cártel de Sinaloa a través del relato de Vicentillo, quien exhibe de manera descarnada cómo funciona el sistema interno que da vida a la organización criminal, la violencia, las mil formas de traficar droga y la complicidad entre políticos, empresarios y fuerzas del orden. Pero sobre todo devela el perfil de quien durante el último medio siglo ha sido el rey del narcotráfico. Quien nunca ha pisado la cárcel y quien desde su trono ha visto caer a amigos, enemigos, socios, competidores, familiares, empleados del gobierno y hasta sus propios hijos, sin que eso haga mella en su poder, el padre de Vicentillo: Ismael el Mayo Zambada.
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Littérature générale (romans)
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There is trouble again in Elf Land. King Gris has escaped with the help of an evil basilisk. If the…
Red Obelisk grants their one wish, the future of Elf Land may be ruined forever. Matt and Liz end up in Elf Land once again, but this time they get help from another Sun Kid. Simple Words Books help struggling readers to become better readers, without tears. Our decodable books support improving their reading fluency, comprehension and confidence. In our books, we use decodable, high frequency and basic sight words that early or struggling readers can easily decode. Our short sentences and paragraphs make it easier for our readers to flow through the chapters. Spelling Pen - Red Obelisk is the second book in the series. It has 18 chapters and over 7500+ words. The entire word list and word frequency are included in the book and on our website (simplewordsbooks.com). We recommend the use of this list as a tool to determine the reading level match and pre-practice with the reader to improve fluency. Check out Simple Words Books at simplewordsbooks.com and Join READlexia Book Club for FREE to receive FREE decodable materials and special offers. Our promise is not to let dyslexia and other learning differences deprive kids of learning the love of reading.
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Informatique et Internet
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Gain a firm practical understanding of how to secure your Linux system from intruders, malware attacks, and other cyber threatsPurchase…
of the print or Kindle book includes a free eBook in PDF format.Key FeaturesDiscover security techniques to prevent malware from infecting a Linux system, and detect itPrevent unauthorized people from breaking into a Linux systemProtect important and sensitive data from being revealed to unauthorized personsBook DescriptionThe third edition of Mastering Linux Security and Hardening is an updated, comprehensive introduction to implementing the latest Linux security measures, using the latest versions of Ubuntu and AlmaLinux.In this new edition, you will learn how to set up a practice lab, create user accounts with appropriate privilege levels, protect sensitive data with permissions settings and encryption, and configure a firewall with the newest firewall technologies. You'll also explore how to use sudo to set up administrative accounts with only the privileges required to do a specific job, and you'll get a peek at the new sudo features that have been added over the past couple of years. You'll also see updated information on how to set up a local certificate authority for both Ubuntu and AlmaLinux, as well as how to automate system auditing. Other important skills that you'll learn include how to automatically harden systems with OpenSCAP, audit systems with auditd, harden the Linux kernel configuration, protect your systems from malware, and perform vulnerability scans of your systems. As a bonus, you'll see how to use Security Onion to set up an Intrusion Detection System.By the end of this new edition, you will confidently be able to set up a Linux server that will be secure and harder for malicious actors to compromise.What you will learnPrevent malicious actors from compromising a production Linux systemLeverage additional features and capabilities of Linux in this new versionUse locked-down home directories and strong passwords to create user accountsPrevent unauthorized people from breaking into a Linux systemConfigure file and directory permissions to protect sensitive dataHarden the Secure Shell service in order to prevent break-ins and data lossApply security templates and set up auditingWho this book is forThis book is for Linux administrators, system administrators, and network engineers interested in securing moderate to complex Linux environments. Security consultants looking to enhance their Linux security skills will also find this book useful. Working experience with the Linux command line and package management is necessary to understand the concepts covered in this book.
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Poésie
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Featured on Quill & Quire's Fall PreviewIf you reloop trauma enough, does it make a danceable rhythm? If you get…
lost in physical sensation enough, does that make you free?DADDY is a powerful look at patriarchy, intergenerational trauma, and queer desire that seeks an unravelling of systems of control to reclaim vulnerability. At once confessional, playful, and sonically meticulous, Byrne's poems seek conversation with a voice in the mind that won't quiet. Cruel father figures dissolve into leather-clad muscle daddies on popper-scented dancefloors; the pain of the past sows the seeds of a joyful exploration of queer desire.
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Politique et gouvernement
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Offers a behind-the-scenes look at the Koch administration and the New York City political machine, profiling the personalities involved in the many scandalous events
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Psychologie, Essais et documents généraux
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Items with ordered response categories are common in survey research, such as when respondents are asked how much they agree…
with certain statements. But how large are the differences between categories of response, and how well do they distinguish between respondents? This volume is the first to introduce the evaluation of rating scales to an audience of survey researchers. Evaluating Rating Scale Functioning for Survey Research provides researchers with an overview of rating scale analysis along with practical guidance on how to conduct such analyses with their own survey data. Author Stefanie A. Wind presents three categories of methods: Rasch models; non-Rasch Item Response Theory (IRT) models; and non-parametric models, together with practical examples. Tutorials, datasets, and software code (R and Facets) to accompany the book are available on the book’s website.
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Essais et documents généraux
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Understanding Statistical Analysis and Modeling is a text for graduate and advanced undergraduate students in the social, behavioral, or managerial…
sciences seeking to understand the logic of statistical analysis. Robert Bruhl covers all the basic methods of descriptive and inferential statistics in an accessible manner by way of asking and answering research questions. Concepts are discussed in the context of a specific research project and the book includes probability theory as the basis for understanding statistical inference. Instructions on using SPSS® are included so that readers focus on interpreting statistical analysis rather than calculations. Tables are used, rather than formulas, to describe the various calculations involved with statistical analysis and the exercises in the book are intended to encourage students to formulate and execute their own empirical investigations.
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Essais et documents généraux
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Ethics in Social Science Research: Becoming Culturally Responsive provides a thorough grounding in research ethics, along with examples of real-world…
ethical dilemmas in working with vulnerable populations. Author Maria K. E. Lahman aims to help qualitative research students design ethically and culturally responsive research with communities that may be very different from their own. Throughout, compelling first person accounts of ethics in human research—both historical and contemporary—are highlighted and each chapter includes vignettes written by the author and her collaborators about real qualitative research projects.
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Essais et documents généraux
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The updated Fourth Edition of Rossman and Rallis’s popular introductory text leads the new researcher into the field by explaining…
the core concepts through theory, research, and applied examples. Woven into the chapters are three themes that are the heart of the book: first, research is about learning; second, research can and should be useful; and finally, a researcher should practice the highest ethical standards to ensure that a study is trustworthy. The Fourth Edition includes an elaborate discussion of systematic inquiry as well as a nuanced discussion of developing a conceptual framework.
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Politique et gouvernement, Essais et documents généraux
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Recognizing that complexity calls for innovative, conceptual, and methodological solutions, this unique book offers practical guidance to policymakers, managers, and…
evaluation practitioners on how to design and implement complexity-responsive evaluations that can be undertaken in the real world of time, budget, data, and political constraints. Introductory chapters present comprehensive, non-technical overviews of the most common evaluation tools and methodologies, and additional content addresses more cutting-edge material. The book also includes six case study chapters to illustrate examples of various evaluation contexts from around the world.
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Essais et documents généraux
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The updated Third Edition of this innovative text shows the unity within the diversity of activities called social research to…
help students understand how all social researchers construct representations of social life using theories, systematic data collection, and careful examination of that data. The book tackles questions like "What is social research?", "How does it differ from journalism, documentary film-making, or laboratory research in the natural sciences?", and "What is the researcher′s obligation to those he or she is studying?" Updated throughout with new references and examples, this edition is designed to evoke challenging questions regarding the nature of representation and the ethical challenges facing social scientific researchers. The text moves beyond standard research challenges to push readers to see the complex relationships among ethics, ideas, evidence, and outcomes.